Abstract:Objective: The aim of this study was to explore the influence of blood lipids, inflammatory factors and endothelial function in patients with acute coronary syndrome after percutaneous coronary intervention(PCI) by Xueshuantong injection. Method: In this study, eighty acute coronary syndrome patients treated by PCI between December 2012 and June 2014 were included, and according to the random numbers, they were divided into treatment group and control group, with 40 cases in each group. The control group was given conventional drug treatment, on the basis of the control group, the treatment group was given Xueshuantong injection for treatment. The lipid level, inflammation factors, endothelial function and adverse reactions before and after surgery were compared. Result: In treatment group, there was no case with thrombolysis in myocardial infarction(TIMI) grade of level 0, 0 case in level Ⅰ, 6 cases in level Ⅱ, 34 cases in level Ⅲ.In control group, there was 0 case in level 0, 0 cases in level Ⅰ, 15 cases in level Ⅱ, 25 cases in level Ⅲ, with significant difference compared to treatment group(P <0.05).After drug intervention for one month after sugery, the levels of total cholesterol(TC), triglyceride(TG), low density lipoprotein-cholesterol (LDL-C) in both two groups were decreased, while the level of high density lipoprotein-cholesterol (HDL-C) was increased, with significance difference (P <0.05). The levels of TC,TG, LDL-C in treatment group was lower than those in control group, the level of HDL-C was higher than that in control group, with significant difference (P <0.05). Preoperative high-sensitivity C-reactive protein(hs-CRP),interleukin-6(IL-6), endothelin(ET),fibrinogen(Fg), von willebrand factor(vWF) one day after surgery were all increased, but with no significant difference between two groups. The hs-CRP, IL-6, ET, Fg, vWF one month after surgery in two groups were decreased with significant difference (P <0.05), and the hs-CRP, IL-6, ET, Fg, vWF one month after surgery in treatment group were lower than those of control group with statistical significance (P <0.05). Within a month after surgery, in control group there were 4 cases for angina pectoris, 1 case for myocardial infarction, the incidence of cardiac event was 12.5%;while in treatment group there were 2 cases for angina pectoris, none for myocardial infarction, the incidence of cardiac event was 5.0%, with no statistically significant differences between two groups. Conclusion: Xueshuantong injection can control postoperative blood lipids in patients with acute coronary syndromes, inhibit inflammation, improve endothelial function,and reduce postoperative cardiac events.
