Abstract:Objective: To observe the curative efficacy of Bushen Yinao decoction combined levodopa in treating Parkinson's disease (PD), and to investigate its influence on oxidative stress and inflammatory response. Method: Eighty patients with PD were randomly divided into the control group (40 cases) and the observation group (40 cases) by a random number table. Patients in the control group received compound carbidopa tablets and selegiline tablets. Based on the treatment of the control group, patients in the observation group added Bushen Yinao decoction. All patients in both two groups received 6 months of treatment. Before and after treatment, scores of unified PD rating scale (UPDRS), PD quality of life scale (PDQ-39), self-rating anxiety scale (SAS), self-rating depression scale (SDS), traditional Chinese medical (TCM) syndrome scores were graded. Levels of superoxide dismutase (SOD), malondialdehyde (MDA), interleukin-1 β (IL-1 β) and interleukin-6 (IL-6) were detected. Result: The total clinical curative rate of in the observation group was 87.5%, which was superior to that of 72.5% in the control group (P <0.05). After treatment, UPDRS Ⅰ-Ⅳ score in the observation group was less than that in the control group (P <0.01). Levels of PDQ-39SI, TCM syndrome score, SAS and SDS in the observation group were inferior to those in the control group (P <0.05, P <0.01). Standards of IL-1 β,IL-6 and MDA in the observation group were lower than those in the control group, while the SOD level was higher than that in the control group (P <0.01). Conclusion: Bushen Yinao decoction combined levodopa could improve motor and non-motor symptoms, enhance patients' quality of life, reduce the side effects of levodopa in treating PD. Its clinical curative effect is superior to using western medicine treatment alone. The mechanism may be related to reducing oxidative stress and inflammation.
