Abstract:Objective: To observe the effect of Ginkgo leaf extract and dipyridamole injection on nerve function recovery in treating hypertensive cerebral hemorrhage (HICH), and to investigate its influence amount of neuron-specific enolase (NSE), serum complement C3, C4 and high sensitive C reactive protein (hs-CRP). Method: Eighty-four patients with HICI were divided into the control group (42 cases) and the observation group (42 cases) according to the order of admission. Patients in two groups received CT guided minimally invasive surgery. After surgery, they received conventional Western medicine treatment including intracranial pressure lowering, blood pressure control, infection control, nerve nutrition, symptomatic, etc. Patients in the observation group added 20 mL Ginkgo leaf extract and dipyridamole injection for intravenous drip twice daily. All patients in both two groups received 14 days of treatment. American nerve function defect of the National Institutes of Health (NIHSS) scores, glasgow coma score (GCS), Fugl-Meyer motor function measure evaluation scores were conducted before and after treatment. Blood plasma NSE, serum C3, C4 and hs-CRP levels were detected. At the seventh and fourteenth day after therapy, NIHSS scores, glasgow coma score (GCS), Fugl-Meyer motor function measure evaluation scores were conducted. The middle line shift situation was evaluated via MRI before and after treatment. Neuron-specific enolase (NSE), serum complement C3, C4 and high sensitive C reactive protein (hs-CRP), tumor necrosis-α (TNF-α) and interleukin 6(IL-6) were tested before and after treatment. Result: The total clinical curative rate in the observation group was superior to that in the control group (P <0.05). NIHSS and GCS scores in the observation group were lower than those in the control group (P <0.01). After treatment, Fugl-Meyer score in the observation group was higher than that in the control group (P <0.01). The improvement of middle line shift situation in the observation group was superior to that in the control group (P <0.01). Levels of NSE, hs-CRP, IL-6 and TNF-α in the observation group were lower than those in the control group (P <0.01). Conclusion: Based on conventional treatment of Western medicine, Ginkgo leaf extract and dipyridamole injection could improve defect of nerve function in HICH patients after minimally invasive surgery, and promote their awakening. The mechanism may be achieved by reducing brain edema and inflammatory reaction.
