Meta-analysis of Yanhuning Injection Combined with Interferon for Treatment of Hand-foot-mouth Disease

Abstract:

Objective: The study aimed to systematically review the clinical efficacy and safety of Yanhuning combined with interferon for curing the hand-foot-mouth disease (HFMD). Method: Using the Cochrane system evaluation method, the retrieval of the Cochrane Library, EMbase, PubMed, CBM, CNKI and Wanfang Data database, a randomized controlled trial of finding out about the Yanhuning and interferon in the treatment of hand foot and mouth disease (RCT), were searched from inception to 2014 September; manual search of relevant conference literature, language and English Chinese limit; 2 reviewers independently screened according to the inclusion and exclusion criteria, extracted data and literature quality evaluation, Meta-analysis was carried out using RevMan 5.2 software. Result: There were 18 studies (2 080 cases) included. The results of Meta-analysis showed that compared to Yanhuning alone, Yanhuning combined with interferon increased the total treatment efficiency of HFMD [OR=3.72,95%CI(2.26,6.11), P <0.000 01], with shorter cooling time [MD=-0.74,95%CI(-1.05,-0.44), P <0.000 01], simplex regression time[MD=-1.17,95%CI(-1.39,-0.96), P <0.000 01], and healing time[MD=-0.83,95%CI(-0.90,-0.76), P <0.000 01]. Compared to interferon alone, Yanhuning combined with interferon increased the total treatment efficiency of HFMD [OR=3.95,95%CI(2.03,7.69), P <0.000 1], with shorter cooling time[MD=-0.60,95%CI(-0.76,-0.45), P<0.000 01], simplex regression time[MD=-0.98,95%CI(-1.12,-0.84), P <0.000 01], healing time [MD=-0.94,95%CI(-1.23,-0.65), P <0.000 01]. Conclusion: The current study showed that Yanhuning combined with interferon are efficacious in the treatment of HFMD than Yanhuning injection alone or interferon alone.