Based on the dual directional thermoregulation of Guizhi decoction (GZD),the effects of its five ingredients on the thermoregulation were observed respectively. The result indicated that GZD had definite effect on dual-directional thermoregulation and Ramulus Cinnamomi,Radix paeoniae Rubra and Radix Glgcyrrhizae could also bidirectionally regulate the body temperature in varing degree. But Fresh Ginger had the action of elevating the temperature in hypothermic body,and Fructus Jujubae had effect of antipyrexia only.