桂枝汤有效部位A对体温的双向调节作用及其机理研究——对大鼠下丘脑PGE2含量的影响

Effect and Mechanism of Active Fraction A of Guizhi Decoctionon(桂枝汤) on Dual-directional Thermoregulation——Effect on Prostaglandin E2 in Hypothalamus of Rats

摘要:

在酵母诱导的发热大鼠中,桂枝汤有效部位A可使下丘脑前列腺素E₂(PGE₂)水平下降;在安痛定诱导的低体温大鼠,则使PGE₂水平升高。

Abstract:

The active fraction A (Fr. A) isolated from Guizhi decoction, which was orally administered, might cut down the rise of body temperature induced by yeast. The Fr.A also went up the hypothermy induced by aminopyrine intravenously. It lowered the content of PGE₂ in febrile rats and raised the content in hypothemic rats in hypothalamus. The results indicate that Fr.A may regulate body temperature in dual-direction by means of promoting or inhibiting the metabolism of PGE₂, a febrile medium in centre.