桂枝汤有效部位A对体温双向调节作用机理研究——对下丘脑三磷酸肌醇和钙调蛋白含量的影响

Effect and Mechanism of Active Fraction A of Guizhi Decoction（桂枝汤）on Dual-Directional Thermoregulation——Effect on IP3and CaM in Hypothalamus of Rats

摘要:

桂枝汤有效部位A(Fr.A)对酵母致热大鼠下丘脑三磷酸肌醇(IP₃)和钙调蛋白(CaM)的降低及安痛定诱致低体温大鼠下丘脑IP₃和CaM含量的升高均有明显的逆转效应,即使高体温大鼠下丘脑IP₃和CaM升高,低体温大鼠IP₃和CaM降低,分别使之趋向正常。结果提示,Fr.A对体温的双向调节有中枢神经细胞内信息传递系统IP₃和CaM参予。

Abstract:

Effect of Fr.A,active fractive A isolated from Guizhi decoction, on inositol 1,4,5 triphosphate (IP₃) and calmodulin (CaM) in hypothalamus in yeast-inducted febrile rats and aminopyrine-induced hypothermal rats was studied. The results showed that IP₃ and CaM contents were significantly decreased in febrile rats,and markedly increased in hypothermal rats. Theose values were reversed to almost normal level in both models after administration of Fr.A. The results suggest that IP₃ and CaM in the thermoregulatory center take part in the dual-directional regulation of Fr.A.