芪附汤对不同状态小鼠Mφ活性及介质的影响

Effect of Qifu Tang(QFT)on Activity of Macrophage(Mφ)and Mediation in Mice with Deficiency of Vital Function

摘要:

选用正常小鼠和氢考阳虚小鼠模型,测其腹腔Mφ活性及分泌介质和相关酶的活性?结果表明,芪附汤可增强小鼠腹腔Mφ活性,可促进阳虚小鼠腹腔Mφ分泌白介素1和肿瘤坏死因子,抑制一氧化氮的生成;明显增强该细胞内精氨酸酶和超氧化物歧化酶的活性?芪附汤还可促进正常小鼠分泌肿瘤坏死因子?降低超氧化物歧化酶的活性?

Abstract:

To investigate the mechanism of promoting vital function of QFT is the purpose of our experiment.QFT was orally respectively administrated normal and abnormal mice with Deficiency of Vital Function (DVF) induced by hydrocortisone(HC) for 14 days and the activity of celiac Mφ,mediates and enzymes were detected.The results showed that QFT could evidently improve the activity of celiac Mφ in normal mice,especially in mice with DVF.In mice with DVF,QFT could decrease the formation of NO,promote Mφ to secrete IL1 and TNF,increase arginase and SOD activities in celiac Mφ.In normal mice,QFT could also promote Mφ to secrete TNF and inhibit SOD activity in celiac Mφ.