六味地黄汤对快速老化模型小鼠(SAM)学习记忆能力的改善作用

Cognition-Enhancing Effect of Liuwei Dihuang Decoction on Age-Related Deterioration of Learning and Memory in Senescence-accelerated Mouse(SAM)

摘要:

采用被动性回避反应?主动性回避反应和水迷宫实验,观察六味地黄汤对快速老化模型小鼠SAMP8记忆获得和记忆保持能力?条件性回避反应能力和空间记忆能力等学习行为功能的影响?结果显示,SAMP8记忆获得和记忆保持能力?条件性回避反应能力及空间记忆能力均明显衰退,长期给予六味地黄汤可提高SAMP8记忆获得和记忆保持能力,改善其空间记忆能力并部分改善其条件性回避反应能力?

Abstract:

Cognition-enhancing effect of Liuwei Dihuang decoction(LW)on SAM was observed by using passive avoidance performance,shuttle box and water maze tests in the present paper.It was showed that memory registration and retention ability,spatial memory as well as conditioned avoid response were all greatly declined in SAMP8.However,chronic administration of LW to SAMP8 enhanced the memory registration and retention ability in passive avoidance performance, promoted the spatial memory ability in water maze test and partially improved the leaning behavior in conditioned avoidance performance.The present results suggested that chronic administration of LW significantly ameliorated agerelated decline of learning and memory ability in SAM.