小儿哮喘直肠凝胶剂的研制——凝胶剂中辅料及促渗剂的选择

Preparation of Xiao'er Xiaochuan Gel in Rectal Administered——Selection of Excipients and Osmotic-promoting Regents

摘要:

采用兔直肠肠系膜静脉插管在体实验方法及HPLC法,测定小儿哮喘直肠凝胶剂直肠给药后指标成分麻黄碱和伪麻黄碱的血药浓度,进行直肠凝胶剂辅料和促渗剂的筛选,结果表明,以油酸和氮酮组成的混合促渗剂及丙烯酸树脂为辅料制成的凝胶剂为佳。

Abstract:

The concentration of ephedrine and pseudoephedrine in rabbit's blood were determined by HPLC method after rectal administered with xiao'er xiaochuan gel.The rectal administered was used by the venous intubation on rabbit's rectal mesentery in vivo. The excipients and osmotic-promoting regents were screened by the blood concentration of above markers.The optimized prescription were made up of oleic acid and azone as osmotic-promoter,and eudragit as excipient.