桂枝汤对体温双向调节作用机理探讨—对下丘脑中腺苷酸环化酶活性及环一磷酸腺苷含量的影响

Mechanism of Guizhi Decoction on Dual-directional Thermoregulation——Effect on AC Activity and cAMP Content in Hypothalamus of Febrile and Hypothermia Rats

摘要:

桂枝汤在对两种不同体温状态模型大鼠呈现解热或升温作用的同时,对酵母诱导的发热大鼠,可显著抑制其下丘脑中AC活性,降低异常升高的cAMP含量;而对安痛定诱导的低体温大鼠,又可显著增强其下丘脑中AC活性,增加异常降低的cAMP含量。实验结果提示:桂枝汤对体温的双向调节作用可能部分是通过影响AC活性,从而改变下丘脑细胞中cAMP含量来实现的。

Abstract:

In febrile rats induced by fresh yeast,Guizhi decoction could cut down body temperature with weakening AC activity and descending cAMP content in hypothalamus.On the other hand,in hypothermia model induced by aminopyrine,Guizhi decoction could go up body temperature with strengthening AC activity and increasing cAMP content in hypothalamus.The results indicate that Guizhi decoction may regulate body temperature in dual-direction by means of effecting AC activity and promoting or inhibiting hypothalamus intracellular metabolism of cAMP,a febrile medium in center.