葛根汤对大鼠佐剂性关节炎防治作用研究

Effects of GeGen Decoction in Preventing and Curing Adjuvant Arthritis in Rats

摘要:

探讨葛根汤对佐剂性关节炎的防治作用。结果表明,葛根汤8.2,16.4gkg致炎前3d灌胃给药,可显著抑制大鼠佐剂性关节炎急性足爪肿胀,对于继发性的足肿胀也有明显的抑制作用。可降低继发性关节炎关节液中的PGE₂的含量。提示葛根汤具有防治佐剂性关节炎的作用。

Abstract:

To study the effects of GeGen Decoction(GGD)in preventing and curing adjuvant arthritis in rats.The results showed GGD(8.2,16.4g/kg,ig)could significantly inhabit primary acute inflammatory swelling and secondary in flammatory reaction by oral administration of GGD three days before modeling.And the level of PGE₂ in joint fluids of secondary arthritis could also decrease.The results indicate GGD can prevent and cure adjuvant arthritis in rats.