中药巴布剂制备工艺的实验研究

Experimental Studies on the Techniques of Cataplasm Contained Chinese Herbal Medicines

摘要:

选用正交实验法,以膏体的均匀性、膜残留性、柔软性、可涂展性及对皮肤的追随性为综合考察指标,以剥离时粘着力(180°)为量化指标,对影响巴布剂膏体物理性状的因素:搅拌时间、炼合温度、各组分基质的添加顺序三个因素进行实验研究,并对最佳条件进行优选。结果表明:制备工艺的最佳条件为:搅拌20～40min;膏体温度50℃;赋形剂组分先与填充剂组合混合后,再加入粘性剂。

Abstract:

The factors effecting the physical property of cataplasm were investigated by means of the homogeneity,layer residue,flexibility and adhesive ability of the plaster as comprehensive consideration,and adhesive force(180°) while exfoliated as the quantitative marker.The main factors,stirring time,refining temperature,and adding order of matrixs were studied by orthogonal design tests.The optimized procedures were stirring for 20～40minute,plaster at 50℃,and after mixing the excipients and filling material,then adding the bonds.