肾复康对大鼠被动型Heymann肾炎的治疗作用研究

Effect of Sheng Fukang on Experimental Passive-Heymann Nephritis in Rats

摘要:

从尿蛋白定量,血清总蛋白、白蛋白、白蛋白球蛋白(A/G)、血胆固醇及血清肌酐和尿素氮含量的变化情况等方面观察肾复康治疗肾小球肾炎的疗效。从血清和肾组织过氧化脂质(LPO)含量、总超氧化物歧化酶(SOD)及谷胱甘肽过氧化物酶(GSH-PX)活性变化探讨肾复康对大鼠被动型Heymann肾炎的治疗机理。结果显示,肾复康显著消除被动型Heymann肾炎模型大鼠尿蛋白,升高血清总蛋白含量、白蛋白、白蛋白球蛋白(A/G)比值,降低胆固醇含量,降低血清肌酐和尿素氮含量,对肾功能具有保护作用。肾复康能显著抑制被动型Heymann肾炎模型大鼠血清和肾组织匀浆LPO的含量升高及总SOD及GSH-PX活性的降低。

Abstract:

The effect of Shengfukang(SFK)was observed by determining the content of urine protein,serum total protein,serum album(A),serum globulin(G),A/G,serum cholesterol,serum creatinine,serum urinary nitrogen.To explore the mechanisms of SFK in treating experimental PHN in rats,the content of LPO and the activity of SOD and GSH-Px in serum and kidney tissue were determined.The results showed that SFK could remarkably eliminate urine protein,while the content of serum total protein,serum album,serum globulin and A/G were increased,And SFK could decreased the content of serum cholesterol,serum creatinine and serum urinary nitrogen.The results also showed that SFK could decrease the content of LPO in kidney and serum,while the activity of SOD and GSH-Px was increased in PHN model rats.