六味地黄丸对甲亢型肾阴虚大鼠滋阴作用的研究

Study of Nourishing Yin Action of Six-Ingredient Rehmannia Pill in the Kindney Yin-deficiency Rats Induced by Hyperthyrea

摘要:

目的:观察六味地黄丸滋阴作用。方法:大鼠灌服3周甲状腺素造成甲亢型肾阴虚模型。结果:六味地黄丸能显著减慢阴虚大鼠心率,减少饮水量,增加尿量和体重,升高血糖、痛阈、甲状腺指数、血清IgG含量,降低血浆粘度,血清T₃、T₄、铜含量及铜锌比值,呈明显剂量依赖关系。结论:六味地黄丸对甲亢型肾阴虚大鼠具有明显滋阴作用。

Abstract:

To observe the nourishing Yin action of Six-Ingredient Rehamnnia Pill (SIRP),Thyroxin (ig) was orally administrated to rats for 3 weeks in order to induce kidney yin-deficiency model of rats.Results showed SIRP markedly decreased the heart rate,plasma viscosity,serum T₃ and T₄,copper,the ratio of copper to zinc,and the intake of water,increased urine output,body weight,blood sugar,pain threshold,Index of thyroid and serum IgG contents.The dose-dependent relationship was significant.SIRP showed significant nourishing Yin action on kidney yin-deficiency rats induced by hyperthyrea.