中药治疗对大鼠慢性肾衰肾功能的影响

Experimental Study of Jiangni Decoction on Rat with Chronic Renal Functional Failure

摘要:

采用大鼠口服腺嘌呤造成慢性肾功能衰竭(CRF)并引起血清中分子量物质(MMS)含量、尿半乳糖苷酶(GAL-ase)排泌增加,观察降逆汤对MMS、GAL-ase等的影响。结果表明:降逆汤对CRF大鼠血清MMS含量的升高及尿GAL-ase排泌的增加具有明显的降低作用。

Abstract:

To observed the therapeutically effects of Jiangni Decoction (JND) on chronic renal functional failure (CRF) induced by adenine in rat. Sprague-Dawley rats fed balance diet containing 0.4% adenine for 4 weeks. We respectively determines the content of the Middle molecular substances (MMS) in serum and the excretion of urinary β-D-Galactosidase (GAL-ase) after treatment with JND. Compared with the pathological model group, the content of MMS in serum and excretion of GAL-ase in urine were markedly decreased in the JND group. The results showed that JND may play an important role in the improvement of rat with CRF.