愈风汤对大鼠短暂脑缺血再灌注后迟发性神经元死亡加重的保护作用

Effect of Yufeng Tang on Preventing Delayed Neuronal Death Worsened by Excitatory Amino Acids

摘要:

目的:研究愈风汤(YFT)对兴奋性氨基酸(excitatory amino acids,EAA)加重迟发性神经元死亡(delayed neuronal death,DND)的防治作用。方法:采用大鼠短暂脑缺血再灌注造成DND动物模型,以氯胺酮为对照,观察YFT对脑缺血再灌注6、24、168h后血清及海马中SOD、MDA含量变化,并用电镜及光镜观察了再灌注168h后海马CA1区的病理变化。结果:YFT可降低DND动物血及海马中MDA含量、增加SOD含量,减轻脑缺血所致病理损害。结论:YFT对EAA加重DND的作用有较好防治作用,且具有量效关系。

Abstract:

To observe the effect of Yufeng Tang(YFT) on preventing delayed neuronal death (DND) worsened by EAA, we used cerebral isocheimal reperfusion model, explored effects of YFT on SOD activity, MDA levels in serum and hippocampus of rats following 6,24,168h after reperfusion was researched. Reperfusion 168h later, cerebral ischemia was observed with light microscope and electron microscope. Result showed YFT enhanced SOD activity, reduced MDA levels in serum and hippocampus, prevented and treated DND in some degree.