梗塞通对动物脑血管的影响

Cerebrovascular Effect of Geng Sai Tong in Animals

摘要:

方法:梗塞通以3个剂量给犬、大鼠及小鼠灌胃给药后,测定麻醉犬的颈总动脉及颈内动脉血流量,测定麻醉大鼠的颈总动脉血流量,测定脑缺血模型大鼠的脑含水量及脑血管通透性,测珲脑血循环障碍及常压下缺氧小鼠的存活时间,测定小鼠的凝血时间。结果表明:梗塞通能明显增加犬、大鼠脑内血流量;能明显降低脑缺血大鼠的脑含水量及脑血管通透性的增加;能显著延长脑血循环障碍及常压下缺氧小鼠的存活时间;也能显著延长小鼠凝血时间。

Abstract:

Geng Sai Tong(GST) was orally administrated to dogs, rats and mice. Then the volume of blood flow in carotid and intra-carotid of anesthetic dogs, and in carotid of anesthetic rats was determined. The water content and the blood vessel permeability of the brain of rats with brain ischemia were checked, The living time of mice under the condition of brain ischemia and without oxygen, and the time of blood coagulation of mice was also checked, The results showed that GST can markedly increase the volume of blood flow in the brain of dogs and rats, and can significantly decrease lift of the water content and the blood vessel permeability of the brain of the rats with brain ischemia, and can markedly prolongate the living time of mice under the condition of brain ischemia and without oxygen and the time of blood coagulation in mice.