健脾降糖饮对四氧嘧啶糖尿病大鼠一氧化氮和内皮素的影响

Effects of Jianpijiangtang Solution on Serum Nitric Oxide and Plasam Endothelin of the Rats with Diabetes

摘要:

为探讨中药健脾降糖饮防治糖尿病(DM)慢性并发症的机理,我们用舌下静脉注射四氧嘧啶(Alloxan)的方法制作糖尿病动物模型,观察健脾降糖饮对DM大鼠空腹血糖、血液流变、血清一氧化氮(NO)和血浆内皮素(ET)的影响。结果显示健脾降糖饮可显著增加体重、降低血糖、改善血液流变、增加NO和降低ET(P均<0.01)。健脾降糖饮对血清NO和ET的干预可能是该方防治DM慢性并发症的机理之一。

Abstract:

To explore the preventive and curative mechanism of Jianpijiangtang Solution(JS) on diabetes rats and its chronic complications, we observed the effect of JS on blood sugar,blood rheology changes, serum nitric oxide(NO) and plasma endothelin (ET) of diabetes rats induced by alloxan. The results showed that JS could improve the blood rheoligy, decrease blood sugar and plasma ET level, and raise serum NO level. The effects of JS on NO and ET are of great importance in diabetes rats and its chronic complications.