养寿丹对阿尔茨海默病肾阳虚大鼠脑神经递质的影响

Effect of Yangshou Dan on neurotransmitters in Rats with Alzheimer's Disease Combining Yang Deficiency of Kidney

摘要:

实验用D-半乳糖腹腔注射致亚急性衰老、醋酸氢化可的松肌肉注射致肾阳虚为基础,合并Meynert核损毁所致Alzheimer型痴呆肾阳虚大鼠模型。通过Y-电迷宫进行大鼠行为测试,并检测脑神经递质。结果表明养寿丹能明显提高该模型大鼠的学习记忆能力,并能增加萎缩的肾上腺重量,提高血清皮质醇含量;对不同脑区降低的单胺类神经递质含量也有不同程度的提高,其中以海马、额叶去甲肾上腺毒(NE)、5-羟色胺(5-HT)更为明显(P<0.01,P<0.001)。

Abstract:

The protective effect of Yangshou Dan(YSD) on central nervous system in rat with AD was studied.Y-electric maze was used to test the ability of learning and memory of rats,and inspect the content of monoamine neurotransmitters by fluorospectrophotometry.The results showed that YSD could significantly improve the learning and memory ability and increase the weight of adrenal,especially,the level of norepinephrine,5-hydroxytryptamine in hippocampus and cerebral cortex.It's suggested that YSD have the protective against the injuring in rat brain through adjusting the level of monoamine neurotransmitters in brain.