“脑还丹”对老龄去势大鼠血清IGF-Ⅰ和血脂水平的影响1

The Influence of Naohuadan on the Level of Serum IGF-Ⅰ and Lipoprotein Metabolism in the Ovariectomized Rat

摘要:

为了探讨“脑还丹”防治神经原退行性变的机制,本文从血清IGF-Ⅰ和血脂的变化观察了该方对老龄去势大鼠(肾虚模型)的病理生理影响。结果表明,“脑还丹”能显著降低卵巢结扎大鼠LDL-c和TC的血清浓度,高剂量可显著提高HDL、TG和血清IGF-Ⅰ的水平。说明“脑还丹”保护神经原的作用是通过调节血脂及IGF-Ⅰ水平等途径实现的。

Abstract:

The research focus on the influence of Naohuandan on the level of serum insulin-like growth factor-Ⅰ (IGF-Ⅰ)and lipoprotein metabolism in order to determine the mechanism of the recipe on neurodegeneration in the ovariectomized rats. The results show that the total cholesterol and low-density lipoprotein cholesterol of Naohuandan groups were significantly lower than that of control group; triglycerides, and high-density lipoprotein cholesterol and serum IGF-Ⅰ of the recipe were significantly higher than that of control group. IGF-Ⅰ between the control group and conjugated estrogen group had significant difference. The results indicate that Naohuandan could effectively regulate the metabolism of lipoprotein and serum IGF-Ⅰ to protect the neurons.