康脑灵胶囊治疗血管性痴呆的实验研究

The Experimental Study of Kangnaoling Capsule on Vascula Dementia

摘要:

目的:研究康脑灵胶囊治疗VD的部分作用机理。方法:采用左心注射液体石蜡致大鼠MID的造模方法,水迷宫实验证实,模型组出现了明显的学习记忆障碍。检测大鼠的学习记忆能力、血液及脑组织SOD、MDA含量、血液流变学指标、红细胞膜脂流动性等。结果:康脑灵胶囊组能显著改善MID大鼠的学习记忆能力,提高模型大鼠血液及脑组织SOD含量(P<0.05),降低模型大鼠血液及脑组织MDA含量,改善大鼠血液流变学指标,提高完整红细胞膜脂流动性。

Abstract:

In experimental study,the MID models were established with male Sistar rats induced by injecting paraffin liquid in left ventricle.The Step-through-water-maze test showed significant deficient of learn and memory function in model group.The results showed significant improvement of the MID model rats' ability of learn and memory,the SOD level of blood,cerebral issues and the index of Hemarrheology and MFU(P<0.05),but decrease of the MAD level of blood and cerebral issues in Kangnaoling Capsule group.