益气活血方对大鼠的调脂作用与NO水平的影响

Effects of Yiqi Huoxue Prescription on Rat Lipid Metabolism and NO Level

摘要:

为了探讨益气活血方对实验性高血脂大鼠血脂、血液流变学、过氧化脂质及内皮舒张因子的影响,用高脂饲料复制实验性高脂血症大鼠模型,按体重和血脂水平随机分组,6周后,取血和肝脏测定上述指标。结果显示,与高脂血症模型组比较,益气活血方能显著地降低实验性高脂血症大鼠的血清总胆固醇(TC),血清甘油三脂(TG)低密度脂蛋白(LDL-C)含量,升高高密度脂蛋白(HDL-C)含量从而改善脂代谢;益气活血方能降低实验高脂血症大鼠血液流变学各项指标,降低全血粘度、血浆粘度、红细胞压积和纤维蛋白含量,益气活血方能降低肝中脂质过氧化反应,降低MDA含量,益气活血方可提高血浆中NO的水平,减少内皮细胞的损伤,保护内皮细胞的完整性。

Abstract:

To investigate the effect of Yiqi Huoxue Prescription on lipid,haemorheology,lipid peroxide (LPO),nitric oxide (NO) in the experimental hyperlipidemia rats,a hyperlipidemia rat model was established by feeding high Lipid diet.The rats were randomly divided by body weight and the level of blood lipid.After 6 weeks,blood samples and livers were collected and determined as above.Results showed Yiqi Huoxue Prescription can effectively decrease the level of TG TC LDL-C and raise the level of HDL-C in the experimental hyperlipidemia rats compared with the model group.Yiqi Huoxue Prescription can also decrease the haemorheologcal parameters,decrease the total viscosity,blood plasma viscosity,hemaocrit and the content of fibrinogen.Yiqi Huoxue Prescription can reduce the lipid peroxide and reduce the content of MDA in liver.Yiqi Huoxue Prescription can increase the content of NO in blood plasma and decrease the endothelial injury and protect the endothelial function.