脑创宁对开放性脑挫裂伤大鼠记忆和血清中ET含量的影响

Effect of Naochuangning on Memory and Endothelin Content in Rats with Open Cerebral Laceration

摘要:

目的:研究脑创宁对开放性脑挫裂伤大鼠记忆力和血清中的ET(内皮素)含量的影响;方法:采用开颅和自由落体法相结合,造成开放性脑挫裂伤大鼠模型。在Y型水迷路中测定大鼠的记忆力;放射免疫法测定血清中ET的含量;结果:脑创宁能明显改善模型大鼠的记忆力,缩短大鼠抵达平台的时间;显著降低血清中的ET含量;结论:脑创宁对开放性脑挫裂伤模型大鼠有一定的治疗作用。

Abstract:

Aim:Effect of Naochuangning on memory and endothelin content in rats with open cerebral laceration was studied.Methods:The methods of opening skull and free falling body was used to cause open cerebral laceration in rats.The memory was determined in Y type water labyrinth,and the content of endothelin(ET) was detected by radioimmunoassay(RIA).Results:Naochuangning remarkably improve intelligence and decrease ET level in serum.Conclusion:The result indicated that Naochuangning had the therapeutic effect on open cerebral laceration in rats.