消黄散对实验性黄疸大鼠NO的影响

Effect of Xiaohuang Granule on No on Experomental Jaundice Rats

摘要:

目的:观察消黄散对实验性黄疸大鼠NO的影响。方法:采用一次性灌胃异硫氰酸萘酯(ANIT)中毒制备大鼠黄疸模型,不同剂量消黄散为治疗组,与思美泰对照,现察血清NO及丙氨酸氨基转移酶(ALT)、总胆红素(TBil)、γ-谷氨酸转肽酶(GGT)、碱性磷酸酶(ALP)和肝组织病理变化。结果:消黄散和思美泰都能显著改善NO及各项指标,结论:消黄散能降低NO水平,抑制其对肝细胞的毒性作用及其与胆汁淤积的相关关系,促进胆红素的正常代谢。

Abstract:

Aim:The effect of Xiaohuang Granule on No on Experomenal Jundice Rats was studied.Methods:The jaundice model of rats was produced by oral administration of ANIT. The changes of NO,ALT, TBil,GGT and pathology of hepatic tissue were observed.Results:Xiaohuang Granule improved the NO level and other indexes.Concluslon: Xiaohuang Granule can reduce content of NO,by which inhibition on the toxicity of hepatic cells and promotion of bilirubin metabolism may be achieved.