丹参、三七的有效部位对正常大鼠血小板粘聚性及TXA2、PGI2的影响

Effects of Active Fractions of Danshen or Sanqi on Platelet Adhesion,Aggregation and TXA2,PGI2 in Normal Rats

摘要:

观察了丹参、三七提取部位丹酚酸B、Rb、Re、Rg对正常大鼠血浆血小板粘聚性及TXA₂、PGI₂的影响。结果表明:灌胃给药,部位Re68mg/kg、Rg108mg/kg对ADP诱导正常大鼠血浆血小板聚集的作用显现出明显抑制作用;部位Rg108mg/kg、丹酚酸B48mg/kg可以明显抑制正常大鼠血浆血小板粘附性;部位Rb112mg/kg对血小板粘聚性均无明显影响;部位丹酚酸B48mg/kg、Rg108mg/kg明显降低血浆TXB₂的水平,对6-Keto-PGF_1α均无明显影响;部位Rg108mg/kg亦明显降低TXB₂6-Keto-PGF_1α的比值。提示:推测丹参、三七有效部位丹酚酸B、Rg抑制正常大鼠血浆血小板粘聚性的作用机理可能与抑制TXA₂的合成有关。

Abstract:

We studied the effects of salvianolic acid B(Sa1.B)、Rb、Re and Rg fractions of Danshen or Sanqi on platelet aggregation and adhesion,TXA₂ and PGI₂ in normal rats. The results demonstrated that Re fraction (68mg/kg)and Rg fraction (108mg/kg),given orally,could markedly counteract ADP induced platelet aggregation.Rg fraction (108mg/kg) and Sal.B fraction(48mg/kg) could markedly inhibit platelet adhesion.Rb fraction(112mg/kg) have no effects on platelet aggregation and on adhesion.Rg fraction(108mg/kg) and Sal.B fraction (48mg/kg) could markedly decrease the level of TXA₂,but had little effect on 6-Keto-PGF_1α. Moreover, Rg fraction 108mg/kg could decrease the ration of TXB₂/6-Keto-PGF_1α,too. The results suggested that the inhibition effects on platelet aggregation and adhesion of Rg fraction(108mg/kg) and Sal.B fraction(48mg/kg) of Danshen or Sanqi might be closely related to its inhibition effect on the release of TXA₂ in normal rats.