芝麻素对肾性高血压大鼠主动脉收缩功能、NO和ET含量的影响

Effects of Sesamin on Contraction of Aortic Ring,NO and ET in Renal Hypertension Rats

摘要:

目的:探讨芝麻素对肾性高血压大鼠的主动脉收缩功能、NO和ET含量的影响。方法:肾性高血压大鼠灌服不同剂量芝麻素(100、33、10mg·kg^-1·d^-1)6周,测定离体胸主动脉环对苯肾上腺素引起的收缩反应、NO和ET含量。结果:100mg·kg^-1芝麻素组主动脉最大收缩张力明显降低,NO含量明显增加,ET含量明显减少(P<0.05)。结论:芝麻素能抑制主动脉收缩,改善血管内皮细胞功能。

Abstract:

Objective:To evaluate the effects of sesamin on contraction of aortic ring,NO and ET in rats with renal hypertension.Methods:Sesamin(100、33、10 mg·kg^-1·d^-1 was orally given in renal hypertensive rats.The responses to phenylephrine on isolated aortic rings was recorded and the levels of NO and ET were measured in aorta after six weeks of treatment.Results:100mg·kg^-1 sesamin could reduce maximum contraction,increase the content of NO and decrease the level of ET(P<0.05).Conclusion:Sesamin can inhibit aortic contraction and improve vascular endothelial cell impairment.