癃闭欣通颗粒镇痛、抗炎及抗菌作用的实验研究

Experimental Study of Longbi Xintong Granule on the Analgesia, Anti-inflmmation and Antimicrobial

摘要:

目的:观察癃闭欣通颗粒的主要药理作用。方法:采用醋酸扭体、热板致痛;二甲苯致耳廓肿胀、棉球肉芽肿、角叉菜胶致足肿胀;体内、外抑菌等试验方法。结果:癃闭欣通颗粒可明显对抗醋酸所致小鼠的扭体次数增加,提高热板所致小鼠的痛阈值;抑制二甲苯所致小鼠耳廓的肿胀度,抑制大鼠棉球肉芽肿的增长,抑制角叉菜胶所致大鼠的足肿胀度,并可对抗大鼠因角叉菜胶所致足组织及血清中PGE₂的含量的升高和对抗大鼠因角叉菜胶所致足组织中MDA含量的升高;同时具有明显的体内外抑菌作用。结论:癃闭欣通颗粒具有明显的镇痛、抗炎、抗菌作用。

Abstract:

Objective:To observe pharmacological effect of Longbi xintong granule.Method:We observed the analgesia effect of the granule by acid induced wristle and hot-plate induced pain in mice.Its anti-inflmmatory effect was tested in xylene caused mice ear edema,cotton caused granuloma hyperplasia in rat,and carrageenin caused paw edema in rat.Its antimicrobial effect was tested in vitro and vivo in mice.Results:Longbi xintong Granule could significantly reduce the wristle reaction times in mice,prolong the latent time of reaction on hot-plate in mice.It could significantly inhibit the ear edema caused by xylene in mice,granuloma hyperplasia caused by cotton and edema of paws caused by carrageenin in rats.Longbi xintong Granule could significantly reduce the content of PGE₂ in paw tissue and serum,and could significantly reduce the content of MDA in paw tissue in inflammatory rats.It could inhibit capillary permeability and improve the antimicrobial activity in vivo and vitro.Conclusion:Longbi xintong Granule has obvious effect on analgesia,anti-inflmmation and antibiosis.