丹皮酚大鼠在体小肠吸收动力学研究

Studies on the Absorption Kinetics of Paeonol in Rat's Intestines

摘要:

目的:研究丹皮酚在大鼠各肠段的吸收动力学特征,为设计丹皮酚新型给药系统提供可靠的生物药剂学依据。方法:应用大鼠在体小肠吸收实验法。结果:丹皮酚在肠道各部位的吸收速率按空肠、回肠、十二指肠、结肠顺序下降,药物在肠道内的吸收呈现一级吸收动力学过程,其吸收机制为被动扩散。结论:丹皮酚适宜设计成为缓释制剂。

Abstract:

Objective:To explore the absorption mechanism of Paeonol from various intestinal segments and offer biophamaceutics data for Paeonol new dosage form.Method:The absorption kinetics and permeability rate constants were investigated by the in situ perfusing method in rats.Result:The absorption rate in rats was descend as the order of jejunum、ileum、duodenum and colon.The absorption of the drug conforms to the first-order kinetics and passive transport machanism.Conclusion:The results indicate that Paeonol can be formulated and prepared as sustained release dosage form.