川贝雪梨膏主要药效学实验研究

Pharmacological Effects of Chuanbei Xueli Extract

摘要:

目的:观察中药复方制剂“川贝雪梨膏”主要药理作用。方法:采用氨水和二氧化硫引咳法,整体平喘和离体试验,酚红祛痰和毛细管排痰法,干酵母和三联菌苗致热和二甲苯和角叉菜胶致炎等方法进行镇咳、平喘、祛痰、解热、抗炎的实验观察。结果:“川贝雪梨膏”能明显延长小鼠的咳嗽潜伏期;对豚鼠的引喘潜伏期有明显的延长,对豚鼠离体气管平滑肌有明显的松弛作用;对小鼠酚红的排出和大鼠的排痰量均有明显增加;对家兔和大鼠的体温升高模型有明显的解热作用;对由二甲苯和角叉菜胶引起的炎性肿胀均有明显的抑制作用。结论:川贝雪梨膏具有明显的镇咳、平喘、祛痰、解热及抗炎作用。

Abstract:

Objective:To investigate the main pharmacological effects of a Chinese traditional compound,Chuanbei Xueli Extract.Methods:The following experiments were carried out:cough induced by ammonia and sulfur dioxide,in vivo and in vitro tests for relieving asthma,phlegm removing with phenol red and capillary,fever caused by dried yeast and triple vaccine,and the inflammation model caused by dimethylbenzene and carrageenin.The effects of the drug on inhibiting cough,relieving asthma,removing phlegm,reducing fever,and antagonizing inflammation were investigated.Results:Chuanbei Xueli Extract significantly prolonged the latent period of cough in mice,increased the latent period of induced asthma in guinea pigs,relaxed the isolated tracheal smooth muscle of guinea pigs,increased the elimination of phenol red in mice,increased the elimination of phlegm volume in rats,lowered the high temperature of rabbits caused by triple vaccine,and inhibited the imflammatorys welling caused by dimethylbenzene and carrageenin.Conclusions:Chuanbei Xueli Extract has significant effects on inhibiting cough,relieving asthma,removing phlegm,reducing fever,and antagonizing inflammation.