黄精多糖的生物活性研究

Biological Activities of Polysaccharides from Polygonatum Sibiricum Redoute

摘要:

目的:研究黄精多糖(PSP)的生物活性。方法:1.饲料中添加PSP,测定PSP对小鼠血脂的影响;2.测定igPSP对小鼠的抗衰老作用;3.测定igPSP对小鼠免疫功能的影响。结果:1.PSP可预防和治疗小鼠高脂血症,降低小鼠血中的胆固醇以及甘油三酯含量;2.PSP可提高7月龄小鼠全血中SOD以及GSH-Px的活性,降低小鼠心、肝、脑组织中LF和MDA含量;3.PSP可提高小鼠腹腔巨噬细胞吞噬百分率和吞噬指数;增加小鼠溶血素的生成;增加正常小鼠DTH反应以及恢复免疫功能低下小鼠的DTH反应。结论:PSP具有降低血脂、延缓小鼠衰老以及增强小鼠免疫功能等作用。

Abstract:

Objective:To research the biological activities of polysaccharide from Polygonatum Sibiricum Redoute.Methods:1.Adding PSP to mouse's feed stuff and determining the inhibition of serum lipids by PSP.2.Feeding mouse with PSP to determine PSP's function of anti-aging.3.Feeding mouse with PSP to determine the immune activities.Results:1.PSP has obvious effect in preventing from and treatment of mouse hypercholesterolemia.2.PSP can increase the activities of SOD and GSH-Px in aged mouse blood and decrease the content of LF and MDA in aged mouse heart,liver() and brain.3.PSP has a strong ability to enhance mouse Phagocyte's Phagocytic percentage and Phagocytic index,to increase the content of haemolysin in mouse and the response of the DTH(delayed-type hypersensitivity) in normal mouse and to recover response to DTH in cyclophosphamide(Cy)intoxicated.Conclusion:PSP can reduce the serum lipids,deter aging and enhance the immune reaction in mouse.