栽培黄芩和野生黄芩抗炎、解热和免疫作用比较研究

Comparative Study on Anti-inflammatory,Antipyretic and Immunomodulation Effects between Extracts from Cultural and Wild Radix Scutellariae

摘要:

目的:探讨栽培黄芩和野生黄芩的抗炎、解热作用和对非特异性免疫功能的影响,并比较它们的药效。方法:以巴豆油致小鼠耳肿胀法和醋酸致小鼠腹腔毛细血管渗出法比较栽培黄芩与野生黄芩的抗炎作用;以干酵母致大鼠发热法比较其解热作用;采用碳廓清实验比较其对非特异性免疫功能的影响。结果:栽培黄芩和野生黄芩均能明显抑制巴豆油致小鼠耳肿胀和小鼠腹腔毛细血管通透性增加、降低干酵母致大鼠发热模型的体温、提高小鼠碳廓清指数(K)值和吞噬指数(α)值。结论:栽培黄芩和野生黄芩都具有抗炎、解热作用,可提高非特异性免疫功能。药效学比较两者无显著性差异,为栽培黄芩代替野生黄芩提供了实验依据。

Abstract:

Objective:To do some comparative study on anti-inflammatory,antipyretic and immunomodulation effects between extracts from cultural and wild Radix Scutellariae.Methods: The anti-inflammatory action was assessed by croton oil-induced ear edema in mice and HAc-induced peritoneal capillary permeability in mice.The antipyretic action was monitored by dried yeast-induced fever in rats.The effect of nonspecific immunity function was detected through the experiment of the clearance rate of charcoal particles in mice.Results: Both extracts from cultural and wild Radix Scutellariae significantly improved the ear edema in mice and inhibited the phlogistic infiltration in mice;The fever induced by dried yeast was reduced by both extracts of Radix Scutellariae;Both extracts of Radix Scutellariae can obviously promote the carbon clearance ability in mice.Conclusion:There is no significant difference in anti-inflammatory,antipyretic and immunomodulation effects between extracts from cultural and wild Radix Scutellariae.The results provide experimental basis for Cultural Scutellariae to replace wild Scutellariae in clinical use.