藏青果喉片药效学研究

Phamacodynamic Studies of Zangqingguo Houpian

摘要:

目的:观察藏青果喉片的主要药效学作用。方法:采用体外抗菌、对2,4-二硝基苯酚所致大鼠发热、巴豆油所致小鼠耳肿胀及角叉菜胶致大鼠胸腔白细胞游走、棉球致大鼠肉芽组织增生、冰醋酸致小鼠疼痛、醋酸泼尼松龙致免疫低下等模型,观察藏青果喉片的药效学作用。结果:藏青果喉片对上呼吸道感染常见的细菌具有不同程序的抑制作用;对2,4-二硝基苯酚致热大鼠有明显的解热作用;并有明显的抗炎作用及显著的镇痛作用;对免疫低下小鼠免疫功能有一定增强作用。结论:藏青果喉片具有抗菌、解热、抗炎、镇痛、免疫调节作用。

Abstract:

Objective:To observe the main pharmacological effects of Zangqingguo Houpian.Method:To observe pharmacological effects of Zangqingguo Houpian on antibacterial effect in vitro,2,4-dinitrophenol induced fever in rats,the croton oil induced swelling in mouse's ear and carrageen induced WBC movement in rat chest,rat granuloma induced by tampon,acetic-acid-induced twisting test in mouse and prednisolone acetate caused immunosuppressive mice.Result: Zangqingguo Houpian could inhibit the growth of bacteria that cause upper respiratory tract infection; restrain the body temperature in fever rats by 2,4-dinitrophenol;and the apparent anti-inflammatory effect and significant analgesic effect;improves immune function on immunosuppressive mice.Conclusion:Zangqingguo Houpian has antibacterial,antipyretic and anti-inflammation,analgesic,immunoregulatory efects.