心康注射液对急性心肌缺血模型大鼠治疗作用的实验研究

Experimental Study on the Treatment of Xinkang Injection on Model Rats with Acute Myocardial Ischemia

摘要:

目的:研究心康注射液对急性心肌缺血模型大鼠的治疗作用并探讨其作用机制。方法:采用冠状动脉结扎制备急性心肌缺血大鼠模型,观察心康注射液对模型大鼠血液中肌酸磷酸激酶(CK)、乳酸脱氢酶(LDH)、丙二醛(MDA)、超氧化物歧化酶(SOD)和ADP诱导的血小板聚集率的影响。结果:心康注射液能明显降低心肌缺血模型大鼠血清中CK、MDA、LDH含量和明显提高血清中SOD含量;心康注射液能够明显抑制心肌缺血模型大鼠的血小板聚集率。结论:心康注射液能降低CK、MDA、LDH含量,提高SOD含量,抑制血小板聚集率,对冠状动脉结扎制备的心肌缺血大鼠模型有较好的防治作用。

Abstract:

Objective:To study the therapeutic effect and mechanism of Xinkang injection on model rats with acute myocardial ischemia.Method: Model rats with acute myocardial ischemia were prepared by coronary artery ligation.The influences on the content of creatine kinase(CK),lactate dehydrogenase(LDH),malonaldehyde(MDA),Superoxide dismutase(SOD) and ADP-induced platelet aggregation rate were observed.Results:Xinkang injection significantly reduced the content of CK,MDA,LDH in serum of model rats with acute myocardial ischemia.Xinkang injection significantly improved the content of SOD in serum of model rats;Xinkang injection reduced the rate of platelet aggregation of model rats.Conclusion: Xinkang injection can reduce the content of CK,MDA,LDH,improve the content of SOD,and inhibit the rate of platelet aggregation.Xinkang injection has a preventive and therapeutic effect on model rats with acute myocardial ischemia prepared by coronary artery ligation.