Objective:To evaluate the efficacy of Tangmaining capsule in the treatment of diabetic peripheral neuropathy.Methods: The treatment group(n=50) received adjuvant therpy of conventional glucose controlled drug with Tangmaining capsule,the control group(n=50) administered Mecobalamin.Both groups were treated for 8 weeks.Results: The total efficacy rate of the treatment showed a significant difference with control group(P<0.05).Compared to the control group,the patients in the treatment group expericenced significant improvements of the MNCV(P<0.01);The SOD level was higher(P<0.01).Conclusion: Tangmaining capsule showed a therapeutic benefit in the treatment of diabetic peripheral neuropathy.