中药合足底反射区按摩对高龄居家女性精神压力和睡眠的疗效研究

Pharmacokinetics of Curcumin Microcystin in Rats

摘要:

目的 :观察足底反射区按摩对老年女性的睡眠和精神压力的影响。 方法 :将40例老年女性对象分为治疗组和对照组,治疗前后测量睡眠质量和精神压力的变化。 结果 :治疗组睡眠改善优于对照组,而精神压力两组有所降低,但无明显差异。 结论 :足底反射按摩对居家女性的睡眠质量改善明显。

Abstract:

Objective: To study the pharmacokinetics of curcumin microcystin in rats. Methods: The microcystin was orally administrated. After carotid artery cannulation, blood samples were collected after administration of 0.08, 0.25, 0.5, 0.75, 1, 2, 3, 4, 5.5 h, and tested by HPLC. Results: The various doses of curcumin concentration-time curve is bimodal; Cmax₁ and Cmax₂ of each dose group are as follows: high-dose(0.90, 1.20 mg/L), medium dose(0.43, 0.46 mg/L), low dose(3.16, 1.31 mg/L); AUC are 3.79, 2.60, 5.92 mg·h/L respectively. Cmax and AUC of low dose are greater than that of the high and medium doses. Conclusion: The Pharmacokinetics of curcumin were nonlinear process in rat, there may be the phenomenon of enterohepatic circulation.