半夏白术天麻汤的组方规律研究

Study on the Composing Rule of Soup of Banxia, Baishu and Tianma

摘要:

目的 :从活性成分角度定量分析探讨半夏白术天麻汤的组方配伍规律。 方法 :按配伍的君臣佐使规律进行拆方,采用HPLC测定不同方中君药天麻代表成分天麻素的含量,从天麻素含量的变化情况分析半夏白术天麻汤的配伍精髓。 结果 :单味天麻中天麻素的含量为11.4 mg/g,天麻+半夏、天麻+橘红、天麻+甘草、天麻+半夏+白术+茯苓+橘红、天麻+半夏+白术+茯苓+橘红+甘草等配伍方中,天麻素的含量均高于天麻单味药的含量测定结果。 结论 :半夏白术天麻汤组方中除白术、茯苓外其他药味对君药天麻的代表成分天麻素的提出率均有不同程度的促进作用。

Abstract:

Objective: To analyze and study the rule of prescription formulation based on the active components of the the Soup of Banxia (Rhizoma Pinelliae), Baishu (Rhizoma Atractyloids Macrocephalae) and Tianma (Rhizoma Gastrodiae). Method :To take apart the soup according to the law of Monarch, Minister, Assistant and Guide, to determine the contents of gastrodin in Tianma which represents the monarch drug in different decomposed recipes using HPLC, and to research the essence of compatibility of the soup from the changes in gastrodin content. Result : The gastrodin in Tianma is 11.4 mg/g, while the levels of gastrodin in Tianma + Banxia, in Tianma +Juhong, in Tianma + Gancao, in Tianma+Banxia+Baishu+Fuling+ Juhong and in Tianma+Banxia+Baishu+Fuling+Juhong + Gancao are all higher than that in Tianma alone. Conclusion: Most of the drugs in the soup except Baishu and Fuling have various degree of promoter action for the extraction yield of gastrodin.