理气调补汤对运动性疲劳大鼠下丘脑-垂体-肾上腺轴的影响

Effect of Liqi Tiaobu Tang on Hypothalamic-Pituitary-Adrenal Axis in Fatigue Induced by Exercise in Rat

摘要:

目的: 探讨理气调补汤对运动性疲劳大鼠下丘脑-垂体-肾上腺轴的调节作用。 方法: 30只健康雄性SD大鼠随机分为3组。采用大鼠游泳运动训练方式,观察大鼠最后1次力竭游泳的力竭时间、血清皮质酮、睾酮、血清和下丘脑β内啡肽含量等指标。 结果: 理气调补汤可以延长大鼠游泳力竭的时间(P<0.01),提高血清睾酮含量;降低血清β内啡肽含量。 结论: 理气调补汤可以改善运动性疲劳大鼠下丘脑-垂体-肾上腺轴的功能,从而起到预防运动性疲劳的作用。

Abstract:

Objective: To observe and to discuss the effect of Liqi Tiaobu Tang on hypothalamic-pituitary-adrenal axis in the rat of fatigue induced by exercise. Method: 30 male SD rats were randomly divided into 3 groups. Ⅰ and Ⅱ groups are all trained for 6 weeks with swimming. The last exhaustive swimming time,serum corticosterone,testosterone, and hypothalamic β-endorphin were observed. Result: Liqi Tiaobu Tang could extend the time for exhaustive swimming in rats(P<0.01),increase the content of T, and decrease the content of serum β-endorphin. Conclusion: Liqi Tiaobu Tang improves hypothalamus-pituitary-adrenal axis function in the rat of fatigue induced by exercise. It may prevent the exercise fatigue.