健骨蠲痹胶囊抗炎镇痛作用的实验研究

Anti-inflammatory and Analgesic Effects of Jiangujuanbi Capsule

摘要:

目的 :观察健骨蠲痹胶囊的抗炎镇痛作用。 方法: 采用弗氏完全佐剂致大鼠足肿胀法、巴豆油致小鼠耳肿胀法、棉球致大鼠肉芽肿法评价药物的抗炎作用;采用扭体法和热板致痛法评价药物的镇痛作用。 结果: 健骨蠲痹胶囊能显著抑制佐剂性关节肿胀,显著减轻巴豆油所致小鼠耳肿胀,减少大鼠棉球肉芽肿的形成。健骨蠲痹胶囊对醋酸及热刺激诱发小鼠的疼痛均具显著的抑制作用。 结论: 健骨蠲痹胶囊具有抗炎和镇痛作用。

Abstract:

Objective: To observe anti-inflammatory and analgesic effects of Jiangujuanbi Capsule. Method: Rat adjuvant arthritis model was established by Freunds complete adjuvant to observe the joint inflammation;mice ear swelling by croton oil was also used.To evaluate the anti-inflamatory action of Jiangujuanbi Capsule, cotton ball granuloma in rats was used.Writhing method and hot plate method were used to observe the Jiangujuanbi Capsules analgesic effect in mice. Result : Jiangujuanbi Capsule could inhibit the rat arthritis,significantly reduce mice ear swelling caused by croton oil,and could reduce granuloma of rats.Jiangujuanbi Capsule reduce obviously the pain of mice which caused by acetic acid and hot plate.Conclusion: Jiangujuanbi Capsule has a good anti-inflammatory and analgesic effects.