异维A酸胶丸联合清肝祛痤方治疗囊肿聚合性痤疮的临床观察

Treatment of Cyst Jialing River Acne with Isotretinoin Soft Capsule Combined with Qing-gan Qu-cuo Recipe

摘要:

目的: 观察和研究异维A酸胶丸(泰尔丝)联合清肝祛痤方治疗囊肿聚合性痤疮的临床疗效。 方法 :50例囊肿聚合性痤疮患者随机分为两组,均给予异维A酸胶丸(泰尔丝)每次20 mg,每天2次口服。治疗组(n=30)在此基础上加用清肝祛痤方,每日1剂,早晚分服,于治疗初始和2,4,8周时观察评价皮损改善,不良反应及16周时的复发情况。 结果 :治疗组有效率90.0%,对照组有效率45.0%。治疗组总皮损均数、炎症性皮损均数、非炎症性皮损均数治疗8周后与治疗前比较,差异有统计学意义(P<0.05或P<0.01)。对照组总皮损均数、炎症性皮损均数治疗8周后与治疗前比较,差异有统计学意义(P<0.05或P<0.01),非炎症性皮损均数治疗8周后与治疗前比较,差异无统计学意义(P>0.05)。治疗组治疗8周后总皮损均数、非炎症性皮损均数与对照组相比较,差异有统计学意义(P<0.05或P<0.01),炎症性皮损均数治疗后两组比较差异无显著性(P>0.05)。 结论 :异维A酸胶丸联合清肝祛痤方治疗囊肿聚合性痤疮疗效肯定,复发率低且不良反应少。

Abstract:

Objective: To observe and study Isotretinoin soft capsules (TaiErSi) combined with Qing-gan Qu-cuo recipe in treating cyst jialing river acne. Method: 50 patients cyst jialing river acne patients were randomly divided into two groups, Isotretinoin soft capsules (TaiErSi) 20mg, 2 times every day. The treatment group (n=30) was added with qing-gan qu-cuo recipe daily.In the treatment of initial and 2, 4, 8 weeks,observing and studying the lesions recovery, assessing skin evaluation for 16 weeks and adverse reaction of recurrence. Result: The efficiency of treatment group and control group was 90.0% vs 45.0%. Total skin lesions means, inflammatory lesions means and noninflammatory lesions means of treatment group 8 weeks after treatment with before treatment, were statistically significant difference (P<0.05 or P<0.01). The control groups total skin lesions means and inflammatory skin lesions means of 8 weeks after treatment compared with before treatment were statistically significant differente (P<0.05 or P<0.01),the noninflammatory lesions means of control group before and after treatment were no significant differente (P>0.05). 8 weeks after treatment, total skin lesions means and noninflammatory skin lesions means of treatment group are better than those of control group significantly(P<0.05 or P<0.01),the inflammatory lesions means of both groups 8 weeks after treatment were no statistically significant difference between the two groups (P>0.05). Conclusion: Isotretinoin soft capsules combined with qing-gan qu-cuo recipe in treating Cyst jialing river acne has reliable effect, low recurrent rate and less adverse reactions.