Objective: To explore the application of association rules in sleep problems of menopause. Method: Association rules analysis was applied to menopause data processing through setting minimum support and minimum confidence,using Apriori algorithm in the process. Result: 23 association rules were discovered between sleep and somatization.symptoms. There were 10 two-way association rules,2 association rules,1 non-association rule. Conclusion: Rules of Sleep problems and Somatic symptoms can be discovered by employing association rules in analyzing menopause cases.And these rules provide im portant reference for prevention and cure of sleep issue.