北豆根总碱分散片的处方优化和稳定性实验

Dispersible Tablets Formulation Optimization and Stability Test of Total Alkaloid of Menispermum Dauricum(TAMD)

摘要:

目的: 确定北豆根总碱分散片的处方并考察其稳定性。 方法: 采用单因素考察和正交实验法,确定北豆根总碱分散片的处方;同时制备3批样品,进行质量考察和稳定性实验。 结果: 优化后的处方可以满足《中国药典》对分散片体外溶出结果的要求。 结论: 该分散片制剂制备工艺简单易行,适合工业化生产。

Abstract:

Objective: To determine the dispersible tablets formulation and investigate its stability. Method: We determine the dispersible tablets formulation by one-factor investigation and orthogonal experimentmethod,at the same time,we prepare the batch sample,then go on quality investigationand stability test. Result: The formulation can satisfy the needs of dissolution rate of the dispersible tablets in vitro in ChP. Conclution: The preparation technology the dispersible tablets is simple and easy progress, and can be used in industrialized production.