紫癜颗粒对免疫性血小板减少性紫癜模型小鼠外周血 白介素-11、转化生长因子β1 的影响

Effects of Purpura Granules on Levels of Interleukin-11 and Transforming Growth Factor-beta1 in Peripheral Blood of Mouse Model with Idiopathic Thrombocytopenic Purpura

摘要:

目的 :通过观察免疫性血小板减少性紫癜(ITP)模型小鼠外周血白介素-11(IL-11)、转化生长因子(TGF-β₁)含量的变化,探讨IL-11,TGF-β₁含量变化与ITP发病之间的内在联系。 方法: 采用酶联免疫方法检测ITP模型小鼠外周血IL-11,TGF-β₁含量变化。 结果: 模型组小鼠外周血IL-11,TGF-β₁含量明显升高,均有统计学意义(P<0.05)。 结论: 调节巨核细胞的正性作用因子IL-11与负性作用因子TGF-β₁参与了ITP的发病过程并发挥重要作用,紫癜颗粒通过调控外周血IL-11,TGF-β₁的含量变化而达到有效治疗ITP的目的。

Abstract:

Objective: To explore the relationship between the changes in interleukin-11(IL-11) and transforming growth factor-beta₁(TGF-β₁) and occurrence of idiopathic thrombocytopenic purpura(ITP)by investigating content of IL-11 and TGF-β₁ in peripheral blood of the mouse model with ITP. Method: Contents of IL-11 and TGF-β₁ in peripheral blood of the mouse model with ITP were measured by ELISA. Result: Contents of IL-11 and TGF-β₁ in peripheral blood of model group increased significantly,and it was statistically significant(P<0.05). Conclusion: IL-11 and TGF-β₁ play an important role in occurrence of ITP,and Purpura Granules can cure ITP effectively by regulating contents of IL-11 and TGF-β₁ in peripheral blood.