香附四物汤与四物汤对急性血瘀模型大鼠血液流变性 及卵巢功能的影响

Evaluating Effects of Xiangfu Siwu Decoction and Siwu Decoction on Hemorheological Indexes and Ovarian Function in Rat Model of Acute Blood Stasis

摘要:

目的 :评价香附四物汤与四物汤对急性血瘀SD大鼠模型血液流变性、凝血功能及卵巢功能的影响。 方法 :采用冰水浴及注射肾上腺素的方法造成SD大鼠急性血瘀模型,对其血液流变性、凝血4项及卵巢分泌功能进行测定。 结果 :香附四物汤能有效改善急性血瘀SD大鼠全血黏度、血沉、红细胞压积,延长TT、APTT,降低FIB至正常水平,对卵巢功能也显示一定改善作用;而四物汤对以上各指标影响不明显。 结论 :在对急性血瘀模型大鼠的生物效应评价中,香附四物汤优于四物汤。

Abstract:

Objective: To evaluate the effects of Xiangfu Siwu Decoction (XFSW) and Siwu Decoction (SW) on hemorheological indexes and ovarian function in rat model of acute blood stasis. Method: A model of blood stasis was established by means of giving rats an injection of adrenalin and making them swim in ice-cold water. The indexes of hemorheology, TT, PT, APTT, FIB, E₂ and P were detected. Results: XFSW showed improvements in the indexes of rats in the model of acute blood stasis, prolonged TT, APTT, degraded FIB to normal level and regulated the secretion of E₂ and P. However, SW showed weak effects on these indexes.