丁香普通粉和超微粉中丁香酚的含量 及对小鼠肠运动作用的研究

Comparison of Eugenol Contents of Micropowder and Coarse Powder of Flos Caryophylli and Their Effects on Intestinal Motility in Mice

摘要:

目的 :比较丁香普通粉和超微粉中丁香酚的含量;研究其对小鼠肠运动作用的影响。 方法 :采用高效液相法测定丁香中丁香酚的含量;采用炭末法观察丁香普通粉、超微粉对小鼠肠运动的影响。 结果: 丁香普通粉和超微粉中丁香酚的含量相同;丁香能显著抑制小鼠的肠运动,超微粉剂量为普通粉的1/4时,仍具有与普通粉相同的作用;丁香超微粉抑制小鼠胃肠运动具有一定量效关系。 结论: 超微粉碎应用于丁香药材具有一定的意义,在临床应用超微细粉时剂量可相应减少,节约药材。

Abstract:

Objective: To study the eugenol contents of micropowder and coarse powder of Flos Caryophylli and the effects on intestinal motility in mice. Method: HPLC was used to determine the contents of eugenol in ultramicro-powder and coarse powder of Flos caryophylli. Charcoal powder propelling test of intestine was used to observe the effects on intestinal mobility in mice for coarse powder and different doses of micropowder. Result: The contents of eugenol were the same in the two kinds of power, Flos caryophylli can obviously inhibit intestinal motility. The effects were the same when the dose of micropowder was 25 percent of that of coarse powder. There was a dose-effect relationship in inhibiting intestinal motility for micropowder. Conclusion: The application of super-crash in Flos caryophylli is significant. The dose of micropowder can be reduced correctly for saving medical material when it is used in clinic.