余甘子抗免疫性肝纤维化大鼠的作用(Ⅱ)

Effect of Phyllanthus emblica on Immune Hepatic Fibrosis in Liver Fibrosis Rats Caused by Porcine Serum(Ⅱ)

摘要:

目的 :观察余甘子对猪血清所致免疫性肝纤维化大鼠的影响。 方法 :采用大鼠ip猪血清,造成大鼠肝纤维化,ig余甘子提取物,检测丙氨酸转移酶(ALT)、门冬氨酸转移酶(AST)、白蛋白(Alb)、球蛋白(GLO)、总蛋白(TP)的含量,计算肝脏系数,并观察肝组织病理形态学变化。 结果 :余甘子提取物能够减少ALT,AST,GLO,TP的含量,升高Alb含量,纠正蛋白倒置,降低肝脏系数;改善肝组织病理损伤。 结论 :余甘子对猪血清致大鼠肝纤维化模型具有较好的保护作用。

Abstract:

Objective: To explore effect of Phyllanthus emblica on immune hepatic fibrosis in liver fibrosis rats caused by porcine serum. Method: The rats were injected with porcine serum, so the rats were got the illness of liver fibrosis, and the rats were given the medicine P. emblica, then the content of ALT, AST, Alb, GLO and TP were tested. Result : P. emblica was able to decrease the content of ALT, AST, GLO, TP, HA, PⅢNP and LN, P. emblica could increase the ALB content also. It was able to improve the inverted protein, rnduce the hepatic weight coefficient and improve the pathological injury of hepatic tissue. Conclusion : P. emblica has protective role in liver fibrosis rats.