芝麻素对乙醇代谢的影响

Effects of Sesamin on the Metabolism of Ethanol

摘要:

目的 :探讨芝麻素对乙醇代谢的影响。 方法 :①不同剂量芝麻素(8,23,70 mg ·kg^-1)对大鼠ig给药14 d后,测定ig乙醇(5 g ·kg^-1)后不同时间点(0.5,1,2,4,6 h)乙醇血液浓度;②不同剂量芝麻素(10,33,100 mg ·kg^-1)对小鼠ig给药7 d后,测定ip乙醇(2.5 g ·kg^-1)后不同时间段(1,2,3,4 h)动物自主活动次数;③不同剂量芝麻素(10,33,100 mg ·kg^-1)对小鼠ig给药7 d后,测定ip乙醇(3.5 g ·kg^-1)后动物翻正反射消失时间的变化。 结果 :①芝麻素23,70 mg ·kg^-1剂量组可显著降低大鼠血液乙醇浓度;②芝麻素33,100 mg ·kg^-1剂量组可使乙醇ip小鼠的自主活动次数增加及翻正反射消失时间缩短。 结论 :芝麻素可促进乙醇的代谢。

Abstract:

Objective: To investigate the Effects of sesamin on the metabolism of ethanol. Method: : ①Sprague-Dawley rats were administrated intragastrically with sesamin at a dose of 8, 23,70 mg ·kg^-1,respectively.After 15d of treatment, ethanol was administrated intragastrically. Blood samples were collected according to the regular time schedule after sesamin administration through vena caudalis. The concentration of norfloxacin was determined by automatic immunoassay analyzer. ②Mice were administrated intragastrically with sesamin at a dose of 10, 33,100 mg ·kg^-1, respectively. After 7d of treatment, ethanol of 2.5g ·kg^-1 was administrated by intra peritoneal injection. Locomotor activity was measured according to the regular time schedule after ethanol was administrated. ③Mice were administrated intragastrically with sesamin at a dose of 10, 33,100 mg ·kg^-1, respectively. After 7d of treatment, ethanol of 3.5g ·kg^-1 was administrated by peritoneal injection. Duration of loss of righting reflex was measured after ethanol was administrated. Result :①Seamin at the dose of 23mg ·kg^-1 and 70mg ·kg^-1 can reduce the blood concentration of ethonal in mice.②Seamin at the dose of 33mg ·kg^-1 and 100mg ·kg^-1 can increase the locomotor activity induced by ethanol in mice. ③Seamin at the dose of 33mg ·kg^-1 and 100mg ·kg^-1 can shorten the ethanol-induced duration of loss of righting reflex in mice. Conclusion: Seamin can accelerate the metabolism of ethanol.