丹红注射液治疗血管性痴呆40例

Clinical Effect of Danhong Injection in 40 Patients with Vascular Dementia

摘要:

目的 :观察丹红注射液治疗血管性痴呆的临床疗效,并探讨其作用机制。 方法 :将80例血管性痴呆患者随机分成丹红注射液治疗组和银杏达莫(杏丁)注射液对照组,在基本药物治疗基础上,静滴上述两种药物,疗程28 d,观察认知功能、日常生活能力、中医证候、血液流变学指标及血浆内皮素1(ET-1)和血清-氧化氮(NO)含量的变化。 结果 :治疗组在认知功能、日常生活能力、血液高切黏度、血液低切黏度和红细胞聚集指数改善方面与对照组作用相当;在改善中医证候、血浆黏度、血浆ET-1和血清NO含量方面治疗组优于对照组(P＜0.05或P＜0.01)。 结论 :丹红注射液治疗血管性痴呆具有较好疗效,其部分作用机制可能与降低血浆黏度、促进脑微血管内皮细胞释放NO、减少释放ET-1、改善舒血管介质和缩血管介质的平衡失调,保护脑微血管内皮细胞功能有关。

Abstract:

Objective: To observe the clinical effect of the treatment with Danhong Injection in the patients with vascular dementia. Method: All 80 patients with vascular dementia were randomly divided into Danhong Injection in the treatment group and ginkgoleaf Extract and dipyridamole injection in the control group, in the treatment of essential drugs, based on the above-mentioned two types of intravenous drugs, the 28-day course of treatment, the cognitive ability,the activities of daily living,TCM symptom of VD, hemorrheology, the content of ET-1 in plasma and NO in serum were measured respectively before and after treatment. Results :The effect was equal between the treatment group and the control group in cognitive function, activities of daily living, blood high-shear viscosity, low shear viscosity and red blood cell aggregation index. In the treatment group in TCM symptom of VD, the plasma viscosity and the content of ET-1 in plasma and NO in serum improvement were better than the control group (P<0.05 or P<0.01). Conclusion :The Danhong Injection treatment of vascular dementia have a better clinical effect, the mechanism may be related to reducing the blood viscosity, and promoting cerebral microcirculatory endothelium to excrete NO,while decreasing ET-1, and improving the balance between vasodilator and vasoconstrictor to protect the brain microvascular endothelial cell function.