香青兰总黄酮渗透泵片的制备及体外释药影响因素考察

Preparation and Influencing Factors on Release of Total Dracocephalum moldevica Flavonoids Osmotic Pump Tablets

摘要:

目的: 制备香青兰总黄酮渗透泵片,并对其体外药物释放影响因素进行研究。 方法: 紫外分光光度法测定渗透泵片体外释放度,考察不同处方和工艺对药物释放的影响。 结果: 促渗剂的种类及用量,碳酸氢钠用量,包衣增重对药物的体外释放均有显著影响。 结论: 渗透泵片制备工艺合理稳定,释药规律符合控释制剂要求。

Abstract:

Objective: To prepare total Dracocephalum moldevica flavonoids osmotic pump tablets and study its factors influencing on drug release in vitro. Method: The UV spectrophotometer was used to determine the release of the osmotic pump tablets, and various factors affected the drug release were studied. Result: The type and amount of penetration enhancers, the amount of sodium bicarbonate, and the coating weight had significant effects on release in vitro. Conclusion: The preparation of osmotic pump tablet is reasonably and stable and the formulations can meet the requirement of the controlled release drug delivery.