苦楝皮化学成分研究

Study on Chemical Constituents of Melia azedarach

摘要:

目的: 研究苦楝皮Melia azedarach L.的化学成分。 方法: 采用硅胶柱色谱技术分离纯化,通过光谱学方法鉴定化合物的结构。 结果: 分离并鉴定出7个化合物,分别为4,8-二羟基-1-四氢萘醌(isosclerone,Ⅰ),梣酮(fraxinellone,Ⅱ), 苦楝皮萜酮(kulinone,Ⅲ), 苦楝萜酮内酯(kulactone,Ⅳ), 南岭楝酮 B (dubione B,Ⅴ), 苦楝酸(kulonic acid,Ⅵ)和 β-谷甾醇(β-sitosterol,Ⅶ),丁二酸(succinic,Ⅷ),5-(羟甲基)-2-呋喃甲醛 。 结论: 化合物Ⅰ,Ⅷ和Ⅸ系首次从该植物中分得。

Abstract:

Objective: To study the chemical constituents of Melia azedarach. Method: The chemical constituents were isolated and purified by column chromatography, and their structures were identified by spectroscopic analysis. Result: Seven compounds were isolated and identified as isosclerone (Ⅰ), fraxinellone (Ⅱ), kulinone (Ⅲ), kulactone (Ⅳ), dubione B (Ⅴ), kulonic acid (Ⅵ), β-sitosterol (Ⅶ), succinic acid (Ⅷ) and 5-(hydroxymethyl)-2-furaldehyde (Ⅸ). Conclusion: CompoundsⅠ,Ⅷ and Ⅸ were isolated from this plant for the first time.